Skip Navigation



Mathematical Medicine and Biology Advance Access published online on July 7, 2009
Mathematical Medicine and Biology, doi:10.1093/imammb/dqp005
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Sotolongo-Grau, O.
Right arrow Articles by Antoranz, J. C.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sotolongo-Grau, O.
Right arrow Articles by Antoranz, J. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The author 2009. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.

Immune system–tumour efficiency ratio as a new oncological index for radiotherapy treatment optimization

O. Sotolongo-Grau{dagger} and D. Rodríguez-Pérez

Dipartimento de Física Matemática y de Fluidos, Facultad de Ciencias, Universidad, Nacional de Educación a Distancia, Senda del Rey 9, Madrid, 28040, Spain

J. A. Santos-Miranda

Servicio de Oncología Radioterápica, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, Madrid, 28007, Spain

O. Sotolongo-Costa

Cátedra de Sistemas Complejos Henri Poincaré, Universidad de la Habana, Habana, 10400, Cuba

J. C. Antoranz

Dipartimento de Física Matemática y de Fluidos, Facultad de Ciencias, Universidad Nacional de Educación a Distancia, Senda del Rey 9, Madrid, 28040, Spain

{dagger} Email: osotolongo{at}dfmf.uned.es

Received on June 28, 2007. Revised on October 31, 2008. Accepted on February 10, 2009.

A dynamical system model for tumour–immune system interaction together with a method to mimic radiation therapy are proposed. A large population of virtual patients is simulated following an ideal radiation treatment. A characteristic parameter, the immune system–tumor efficiency ratio (ISTER) is introduced. ISTER dependence of treatment success and other features are studied. Radiotherapy treatment dose optimization, following ALARA (As Low As Reasonably Achievable) criterion, as well as a patient classification are drawn from the statistics results.

Keywords: modeling; optimization; radiotherapy; simulation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.