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Mathematical Medicine and Biology Advance Access originally published online on October 27, 2006
Mathematical Medicine and Biology 2007 24(1):85-109; doi:10.1093/imammb/dql025
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© The author 2006. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.

Idiopathic intracranial hypertension and transverse sinus stenosis: a modelling study

Scott A. Stevens**,1, Michelle Previte1, William D. Lakin2, Nimish J.Thakore3, Paul L. Penar4 and Brandon Hamschin5

1 School of Science, Penn State Erie, The Behrend College, Erie, PA 16563-0203, USA, 2 Department of Mathematics and Statistics, University of Vermont, Burlington, VT, USA, 3 MetroHealth, Department of Neurology, Case Western Reserve University, Cleveland, OH, USA, 4 Department of Surgery, Division of Neurosurgery, College of Medicine, University of Vermont, Burlington, VT, USA, 5 School of Science, Penn State Erie, The Behrend College, Erie, PA, USA

** Email: sas56{at}psu.edu


  Abstract

Idiopathic intracranial hypertension (IIH) is a syndrome of unknown etiology characterized by elevated intracranial pressure (ICP). Although a stenosis of the transverse sinus has been observed in many IIH patients, the role this feature plays in IIH is in dispute. In this paper, a lumped-parameter model is developed for the purpose of analytically investigating the elevated pressures associated with IIH and a collapsible transverse sinus. This analysis yields practical predictions regarding the degree of elevated ICPs and the effectiveness of various treatment methods. Results suggest that IIH may be caused by a sufficiently collapsible transverse sinus, but it is also possible that a stenosed sinus may persist following resolution of significant intracranial hypertension.

Keywords: lumped-parameter model; intracranial pressure; idiopathic intracranial hypertension; cerebrospinal fluid; venous sinus.

Received on 21 November 2005. accepted on 4 September 2006.


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