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Mathematical Medicine and Biology Advance Access originally published online on August 11, 2008
Mathematical Medicine and Biology 2008 25(3):233-245; doi:10.1093/imammb/dqn016
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© The author 2008. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.

An enzyme kinetic model of blood island formation

Andrew Matteson{dagger}

Department of Mathematics, Mailstop 3368, Texas A & M University, College Station, TX 77843-3368, USA

{dagger} Email: drew.matteson{at}gmail.com

Received on September 20, 2007. Revised on May 5, 2008. Accepted on July 2, 2008.

Blood islands are conglomerations of prevascular stem cells that form during vasculogenesis, a function critical to early vascular and hematopoietic development. In this paper, a model of blood island formation is proposed employing the approach of classical enzyme kinetics. Deterministic simulations of the model show the formation of blood island-like structures. These are compared to murine blood islands.

Keywords: Blood islands; GATA-2; reaction-diffusion equations; hematopoiesis; vasculogenesis


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